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Abstract Title:Acupuncture Alleviates Corneal Inflammation in New Zealand White Rabbits with Dry Eye Diseases by调节7NACHR和NF-B信号通路。
摘要来源：
基于EVID的补体替代药物。 2022; 2022：6613144。 EPUB 2022 11月14日。pmid： 36419616 36419616 Chengyong Liu, Yongcheng Ni, Jun Zhao, Wanli Xu, Weiping Gao
Article Affiliation:Ning Ding
Abstract:PURPOSE: The purpose of this study is to determine the mechanism of improvement in dry eye diseases (DEDs) treated by acupuncture.在我们的研究中将分析炎症分子和相关途径。
mEthods： 为了建立DED的动物模型，健康的新西兰白兔子连续21天用scopolamine（SCOP）氢无球治疗。 After 21 days, acupuncture, fluorometholone (Flu), and7nAChR antagonist (-BGT) treatments were performed, and the Scop injections were continued until day 35. The therapeutic effect of acupuncture on DED inflammation was evaluated by corneal fluorescence staining, tear film rupture time, tear flow measurement, in vivo confocal microscopy (IVCM), corneal histopathology,和细胞因子蛋白芯片技术。 The influence of acupuncture on the corneal pathology and inflammatory factors ACh,7nAChR, and NF-B was detected by enzyme-linked immunosorbent assay (ELISA) and western blot.
RESULTS: Compared with the group Scop, acupuncture can significantly reduce corneal staining and increase the tear film破裂的时间和撕裂流，伴随着D角膜上皮脱离和淋巴细胞浸润的ecrease。针灸可以减轻角膜基质的炎症，并减轻促炎因子和趋化因子的表达。 Acupuncture can upregulate the expression of ACh and7nAChR and downregulate the expression of NF-B.
CONCLUSION: Our findings demonstrate that acupuncture can alleviate corneal inflammation in New Zealand white rabbits with DEDs via7nAChR and NF-B signaling pathway regulation.该表达式表明7NACHR/NF-B信号通路可能是有效的，并且针灸是干眼症的潜在治疗靶标。