j Ethnopharmacol。 2024年1月10日； 318（pt b）：117065。 EPUB 2023 8月19日。PMID： 37604330“> 37604330 Peng Sun, Yue Ma, Dong Zhang, Ya Zhao, Haidong Jia
Article Affiliation:Yifan Zhao
Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: Artemisia annua L. belongs to the Asteraceae family and has a long history of clinical application in China.它已被广泛用于几个世纪以治疗发烧，疟疾，黄疸和一些皮肤病（例如疮和疮）。现代药理studies表明，它具有抗炎，免疫调节性，抗菌和抗菌作用。
研究的目的： 这项研究旨在研究旨在调查A. annua A. Annua squement and Insport and Itscation and Itsact的抗eCzema效应（A。基本机制。
材料和方法： 使用MTT分析来评估AAE的细胞毒性。使用体外3D表皮炎症模型和体内豚鼠瘙痒模型评估了AAE的抗Zema效应。 The bioactive components of AAE were characterized by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry coupled with the UNIFI platform.
RESULTS: In this study, we found that AAE is safe for primary human skin keratinocytes at concentrations ranging from31.3μg/ml至250μg/ml。进一步的研究表明，AAE可以增加瘙痒阈值，抑制炎症性细胞因子TSLP的表达，并促进FLG mRNA的表达。 Additionally, the utilization of UPLC-QTOF/MS and UNIFI platform enabled us to identify 61 potential bioactive components of AAE, with sesquiterpenes and phenolic acids being the most abundant components.
CONCLUSIONS: In this study, the anti-inflammatory and anti-itch effects of根据文献，将A. annua提取物与倍半萜一起揭示为酚烯酸，酚酸被确定为潜在的生物活性成分。 AAE提取物具有用于治疗湿疹的潜力。