维生素C具有抗炎作用，与没有心血管疾病史或糖尿病病史的男性中的内皮功能障碍有关

维生素C状态，水果和蔬菜摄入量以及炎症和止血的标志的关联。

am j Clin Nutr。 2006年3月； 83（3）：567-74；测验726-7。 PMID： 16522902“> 16522902 Bruckdorfer, Peter H Whincup

S Goya Wannamethee

BACKGROUND: It has been suggested that a high dietary intake and high circulating concentrations of vitamin C may protect against ischemic heart disease.

目标： 目的是检查饮食和血浆维生素C浓度，水果和蔬菜摄入量以及炎症和止血的标志与心血管疾病有关diovascular disease.

DESIGN: This cross-sectional study examined 3258 men aged 60-79 y with no physician diagnosis of myocardial infarction, stroke, or diabetes and who were drawn from general practices in 24 British towns. Fruit and vegetable intakes and dietary vitamin C were assessed by using a food-frequency questionnaire.

RESULTS: Plasma vitamin C, fruit intake, and dietary vitamin C intake were significantly and inversely associated with mean concentrations of C-reactive protein, an acute phase reactant, and tissue纤溶酶原激活剂（T-PA）抗原，即即使在调整混杂因子后，内皮功能障碍的标志物也是如此。蔬菜摄入量仅与T-PA显着相关（成反比）。对于血浆维生素C（最高与最低的四分位数），C反应蛋白和T-PA的调整后几率（最高三位分与最低三重）为0.56（95％CI：0.44，0.71）和0.79（0.62，1.00）;对于水果摄入，相应的优势比为0.76（0.60，0.95）和0.76（0.61，0.95）。血浆（但不是饮食）维生素C也显示出与纤维蛋白原浓度和血液粘度的逆关联。没有看到与von willebrand因子或VIII因子。

结论： 这些发现表明，维生素c具有抗炎作用，并且与较低的内皮性病史或无脑膜炎病史有关，或者与Cardiovastial病史相关。糖尿病。