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Abstract Title:Regular exercise during haemodialysis promotes an anti-inflammatory leucocyte profile.
Abstract资料来源:
临床肾脏J. 2017年12月; 10(6):813-821。 EPUB 2017 3月27日。PMID: 292225811“> 292225811 Churchward,James O Burton,Alice C Smith,Nicolette c Bishop
文章隶属关系:Maurice Dungey
摘要:
Methods: Twenty-two HD patients from a centre where intradialytic cycling was offered thrice weekly and 16 HD patients receiving usual care volunteered.锻炼患者的旨在在感知劳累的评级时循环30分钟。将基线特征与16个健康年龄匹配的个体进行了比较。 Physical function, soluble inflammatory markers and leucocyte phenotypes were assessed again after 6 months of regular exercise.
Results: Patients were less active than their healthy counterparts and had significant elevations in measures of inflammation [interleukin-6 (IL-6), C-reactive protein (CRP),肿瘤坏死因子-α(TNF-α),中间和非经典单核细胞;所有p <0.001]。六个月的定期同烯练习改善了身体乐趣ction(坐姿60)。 6个月后,与非运动员相比,运动患者的中间单核细胞比例减少(7.58±1.68%至6.38±1.81%,而6.86±1.45%至7.88±1.66%; p <0.01)。在非锻炼患者中,调节性T细胞的数量(但不比例)仅减少(p <0.05)。训练对循环IL-6,CRP或TNF-α浓度没有显着影响。
结论: 这些发现表明,定期进行辐射内运动与循环细胞级别的抗炎作用相关,但不循环循环。这可能可以防止与慢性炎症和中间单核细胞数量升高有关的心血管疾病和死亡率的风险增加。