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Abstract Title:Beet supplementation mitigates post-exercise inflammation.
Abstract Source:
前营养。 2024; 11:1408804。 EPUB 2024 5月30日。PMID: 38873567> 38873567 Williams, Fayaj A Mulani, Patil Shivprasad Suresh, Ashraf M Omar, Qibin Zhang
Article Affiliation:David C Nieman
Abstract:OBJECTIVES: This study investigated the efficacy of a mixed beet-based supplement (BEET) versus placebo (PL)在恢复过程中,有20位男性和女性骑自行车的人在恢复2.25小时的恢复过程中应对炎症。使用了包括未靶向蛋白质组学和靶向的氧蛋白面板的多摩学方法。
方法: 使用了一个随机的,安慰剂控制的,双盲的,跨界设计,并在两个2周的补充周期和2周的清洗期间使用。补充周期之后是2.25 h循环回合,接近70%的VO。甜菜补充剂每天提供212毫克的硝酸盐,绿茶提取物的200毫克咖啡因,44毫克的维生素C,来自Camu Camu Berry的44毫克维生素C,来自藜麦芽的B-景素(每天40%的硫代,核黄素,烟碱,烟碱和维生素B6和Vitamin b6)和2.5 g的Olbriquiquiquiquiquiquiquiquiquiquiquiquiquiquiquiquiquiquiquiq and corders and corders andons and conson和2.5 g。 Six blood samples were collected before and after supplementation (overnight fasted state), immediately post-exercise, and at 1.5 h-, 3 h-, and 24 h-post-exercise.
RESULTS: The 2.25 h cycling bout increased plasma levels of 41 of 67 oxylipins detected.甜菜补充显着增加了血浆硝酸盐(NO)和亚硝酸盐(NO)(sum,no++) NO)浓度(相互作用效果,<0.001)和两种抗炎脂蛋白[18-羟基糖果酸烯酸(18-Hepe)和4-羟基二甲苯性己糖酸(4-HDOHE)]。未靶向的蛋白质组学分析鉴定出616种蛋白质(所有时间点458个),2路ANOVA揭示了一组45种蛋白质的簇,这些蛋白质降低,在甜菜与PL试验中增加了21个簇。 Functional enrichment supported significant BEET-related reductions in inflammation-related proteins including several proteins related to complement activation, the acute phase response, and immune cell adhesion, migration, and differentiation.
DISCUSSION: Intake of a BEET-based supplement during a 2-week period was linked to higher plasma NO+NO的水平,运动后水平升高的两种抗炎药的水平,以及参与补体激活和炎症的一组蛋白质簇的显着降低。这些数据支持从基于甜菜的混合补充剂蛋白质生物标志物中摄入2周的硝酸盐摄入运动员的运动引起的炎症。