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Abstract Title:Effects of Sesame Consumption on Inflammatory Biomarkers in Humans: A Systematic Review and随机对照试验的荟萃分析。
摘要来源:
基于EVID的补体替代药物。 2021; 2021:6622981。 EPUB 2021 11月1日。PMID: 34760018> 34760018 Alireza Yargholi, Mohammad Ali Zareian, Jessie Hawkins, Nitin Shivappa, Laila Shirbeigi
Article Affiliation:Shabnam Rafiee
Abstract:Objectives: Existing evidence produces conflicting findings regarding the effect of sesame intake on炎症生物标志物;通过系统的审查和荟萃分析,这种知识差距尚未得到满足。这项荟萃分析of randomized, controlled clinical trials (RCTs) was conducted to evaluate the effects of sesame consumption on markers of inflammation in humans.
Methods: PubMed, Scopus, and the Cochrane Database of Systematic Reviews were searched through August 2020 to identify relevant papers for inclusion.使用随机效应模型,将数据评估为具有95%置信区间(CI)的加权平均差异(WMD)。 Cochranesand-squared () tests were used to identify within-studies heterogeneity.
Results: Seven RCTs with 310 participants (157 intervention and 153 control) were included in the meta-analysis.与对照组相比,芝麻消耗降低了血清介绍介素-6(IL-6)(WMD-0.90; 95%CI(-1.71,-0.09),= 80.4%)。但是,芝麻的摄入对C反应蛋白(CRP)和肿瘤坏死因子(TNF-)没有显着影响trol组。亚组分析确定了在基线时具有更高水平的这些生物标志物的参与者的研究中,血清CRP,TNF-和IL-6浓度的降低,使用芝麻蛋白胶囊的研究者以及在亚洲进行较大样本大小的那些,在亚洲进行的,以及对女性进行的研究。 芝麻消耗降低了IL-6的血清水平,但不会影响CRP和TNF-IN人类。应使用较大且更长的治疗持续时间以及使用不同芝麻制剂(胶囊,石油和种子)以及对具有不同健康状况的参与者进行的研究。
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