抑制北氢糖酸酸的人类胎儿膜绒毛膜细胞中流感病毒诱导的细胞凋亡。
摘要来源：
Interivecrology。 2005; 48（5）：336-40。 PMID： 15956802” Toyoda
Article Affiliation:Noboru Uchide
Abstract:OBJECTIVES: It has been postulated that the pathogenesis of influenza virus infection involves not only the virus-proliferation-mediated apoptotic cell death in infected cells, but also a direct reactive oxygen species (ROS)-induced感染器官的细胞损伤。我们检查了抗氧化剂，北多糖酰亚热素（NDGA）对凋亡诱导和病毒增殖的影响。随后，将结果与吡咯烷二硫代氨酸吡咯烷（PDTC）的结果进行了比较。IDANT。
方法： 用2,7-二氯氟乙酸酯测量ROS产生的水平；分别通过DNA碎片和形成斑块形成测定法分析了凋亡诱导和病毒增殖。
结果： NDGA用NDGA治疗NDGA抑制过量生产，脂肪的DNA eRIPTOTION DNA eRIFTIFERTIFER，病毒均匀的细胞处理。用500 microm NDGA观察到对DNA碎片化的最大抑制作用（76％）。 The antiviral activity of NDGA against influenza virus was more potent than that of PDTC.
CONCLUSIONS: The present study, therefore, suggests for the first time that NDGA, a known antioxidant reagent, inhibits the induction of apoptosis in human fetal membrane chorion cells infected与PDTC相比，通过更有效的抗病毒活性，流感病毒。>