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Abstract Title:Beneficial effects of combined resveratrol and metformin therapy in treating diet-induced insulin电阻。
摘要来源：
PhysiolRep。2016Aug; 4（15）。 PMID： 27482073
atbress abracsive wurs（s）隶属关系：Scott Frendo-Cumbo
摘要：多酚化合物白藜芦醇（RSV）由于其对胰岛素敏感性的有益作用而引起了人们的注意。我们的实验室先前已经确定了RSV对大鼠2型糖尿病的发展的保护作用。这些作用以类似于噻唑烷二酮（TZDS）的方式发生，这是一类胰岛素敏化药物。 TZD通常与M结合使用Etgrigin（Met），因此我们试图检查RSV和MET在治疗胰岛素抵抗中的综合作用。雄性C57BL6小鼠被低 - 脂肪（HFD; HFD; 60％kcal from Fat）喂食9周，以诱导葡萄糖和胰岛素不耐症。 HFD mice were then assigned to control (HFD), MET (231.28 ± 12.24 mg/kg/day), RSV (93.68 ± 3.51 mg/kg/day), or combined (COM; MET 232.01 ± 17.12 mg/kg/day and RSV 92.77 ± 6.92 mg/kg/day) treatment groups.治疗后4周测量葡萄糖和胰岛素耐受性以及组织特异性胰岛素信号的变化。 RSV or MET alone did not have beneficial effects on glucose tolerance, although MET significantly improved insulin tolerance compared to HFD Glucose and insulin tolerance were significantly improved in COM compared to HFD and this was mirrored by enhanced insulin-stimulated AKT phosphorylation in triceps muscle and inguinal subcutaneous adipose tissue in COM compared to HFD mice. com Treat的改进体重，肥胖或脂肪组织炎症的标志物的差异没有解释。总而言之，这项研究提供了RSV合并和MET治疗在治疗葡萄糖稳态损伤方面的有益作用的证据。