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Abstract Title:Consumption of Whole Eggs Promotes Insulin Sensitivity in Db/db Mice (OR34-01-19)。
摘要来源:
curr dev nutr。 2019 Jun; 3(补充1)。 EPUB 2019年6月13日。PMID: 31225044444 "> 31225044 Stephen Clarke,Edralin A Lucas,Brenda Smith,Winyoo Chowanadisai,Weiqun Wang,Denis Medeiros,Dingbo lin
文章隶属关系:peiran lu
摘要:
Methods: Six-week-old male db/db mice were fed a low-fat diet (LFD, 10 kCal % from fat) or LFD补充了1%的全鸡蛋(鸡蛋)8周。在研究终止时,将小鼠禁食3小时,然后安乐死。收集血液和其他组织进行实验室评估。血浆代谢参数和促炎细胞因子分别通过临床分析仪和ELISA监测。通过海马Xfanalyzer评估了肝和骨骼肌线粒体呼吸活性。通过转录组学分析了肝基因表达,并通过实时PCR和/或Western blot确认。
结果: Egg消耗显着增加了体重增益,降低空腹血糖,胰岛素和IL-6水平,总胆固醇,HDL,LDL和GLP-1水平升高。仅降低了基础线粒体呼吸活性,并且在喂养卵的小鼠胃肌中,复合物II呼吸活性增加。饮食不会改变肝线粒体活性。 Mechanistically, transcriptomics results revealed that hepatic genes involved in enhanced insulin sensitivity were highly expressed, but genes in endogenous cholesterol synthesis were significantly suppressed after egg consumption.
Conclusions: The results suggest that egg consumption is beneficial to blood glucose control in type 2 diabetic老鼠。 2型糖尿病动物可以通过抑制胆固醇的合成来管理胆固醇水平,例如,例如,鸡蛋饮食。Ition Center Grantusda Nifa Grant。