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Abstract Title:Dose-Responses Relationship in Glucose Lowering and Gut Dysbiosis to Saskatoon Berry高脂蔗糖饮食诱导的胰岛素耐药小鼠中的粉末补充。
抽象来源:
微生物。 2021年7月21日; 9(8)。 EPUB 2021 7月21日。PMID: 34442633 34442633 Shen
Article Affiliation:Ruozhi Zhao
Abstract:Administration of freeze-dried powder of Saskatoon berry (SB), a popular fruit enriched with antioxidants, reduced glucose level, inflammatory markers and gut microbiota disorder in high fat-high sucrose (HFHS) diet-induced insulin resistant mice.本研究检查了代谢,炎症和肠道微生物的剂量反应关系HFHS饮食喂养小鼠中补充SB功率(SBP)的变量。雄性C57 BL/6J小鼠在11周内喂食HFHS饮食,补充了0、1%,2.5%或5%的SBP。 HFHS diet significantly increased the levels of fast plasma glucose (FPG), cholesterol, triglycerides, insulin, homeostatic model assessment of insulin resistance (HOMA-IR), tumor necrosis factor-α, monocyte chemotactic protein-1 and plasminogen activator inhibitor-1, but decreased fecalphylum bacteria andfamily bacteria compared to low fat diet.与仅接受HFHS饮食的小鼠相比,SBP剂量依赖性地降低了小鼠的代谢和炎症变量以及肠道营养不良。在接受≥1%SBP的小鼠中检测到HFHS饮食诱导的生化疾病的大量衰减。小鼠的体重,FPG,脂质,胰岛素,HOMA-IR和炎症标志物与体重,FPG,脂质,HOMA-IR和炎症标记有负相关。结果表明,补充剂量依赖于hfhs饮食诱导的代谢剂的剂量依赖性剂量IC和炎症性疾病,与小鼠肠道营养不良的改善有关。