含含含木霉素的含有γ-亚麻酸的饮食可减弱博来霉素诱导的仓鼠肺纤维化。
脂质。 1997年7月; 32（7）：759-67。 PMID： 9252965“> 9252965 尽管使用抗肿瘤药物（BLM）用于治疗多种肿瘤，但有助于其诱导的肺损伤和纤维化的机制尚未完全阐明。 Since alterations in the levels of certain fatty acid metabolites have been associated with BLM-induced lung injury, we tested the effects of dietary gamma-linolenic acid (GLA)-containing evening primrose oil on BLM-induced morphological alterations in the hamster lung, the marked elevation of tissue hydroxyproline (a marker for collagen synthesis), and elevated generation of arachidonic acid代谢物（炎症介质的标记）。 Our data revealed that after 14 d of dietary GLA-containing oil (i) BLM-induced elevation of lung hydroxyproline was suppressed (P <0.05), (ii) the marked BLM-induced elevation of lung leukotriene B4 (LTB4) (a marker of polymorphanuclear generation of proinflammatory LTB4) was significantly suppressed (P <0.05). LTB4的降低伴随着肺前列腺素E1（PGE1）和15-羟基羟基苯甲酸（15速）的明显升高（P <0.05），均具有已知的抗炎特性。 总的来说，这些研究的数据表明，含膳食GLA的油有助于PGE1和15速率的组织升高，在体内可能减轻肺部炎症和纤维化。
尽管使用抗肿瘤药物（BLM）用于治疗多种肿瘤，但有助于其诱导的肺损伤和纤维化的机制尚未完全阐明。 Since alterations in the levels of certain fatty acid metabolites have been associated with BLM-induced lung injury, we tested the effects of dietary gamma-linolenic acid (GLA)-containing evening primrose oil on BLM-induced morphological alterations in the hamster lung, the marked elevation of tissue hydroxyproline (a marker for collagen synthesis), and elevated generation of arachidonic acid代谢物（炎症介质的标记）。 Our data revealed that after 14 d of dietary GLA-containing oil (i) BLM-induced elevation of lung hydroxyproline was suppressed (P <0.05), (ii) the marked BLM-induced elevation of lung leukotriene B4 (LTB4) (a marker of polymorphanuclear generation of proinflammatory LTB4) was significantly suppressed (P <0.05). LTB4的降低伴随着肺前列腺素E1（PGE1）和15-羟基羟基苯甲酸（15速）的明显升高（P <0.05），均具有已知的抗炎特性。 总的来说，这些研究的数据表明，含膳食GLA的油有助于PGE1和15速率的组织升高，在体内可能减轻肺部炎症和纤维化。
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