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Abstract Title:Hydrogen inhalation is neuroprotective and improves functional outcomes in mice after intracerebral出血。
摘要来源:
acta Neurochir Suppl。 2011; 111:179-83。 PMID: 21725752“ Ostrowski,John H Zhang,Jiping Tang
文章隶属关系:anatol manaenko
摘要:
客观: 氧化应激对脑损伤的发育显着促进了脑损伤的发育。以前已经证明,氢气可以通过清除活性氧降低氧化应激。我们假设氢治疗将减少脑氧化ive stress in mice after ICH and thereby will lead to reduced brain edema and improved neurological outcomes.
MATERIALS AND METHODS: CD1 male mice (weight 30-35 g) were divided into the following groups: sham, ICH+vehicle (room air), ICH+1-h hydrogen treatment, and ICH+2-h hydrogen 治疗。通过将细菌胶原酶注入右基底神经节来诱导ICH。结果的评估是在两个时间点进行的:24和72小时。测量脑水含量以评估脑水肿(湿/干重法),并在术后和术后进行了三项神经系统测试。
结果: <> <> <> <>