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Abstract Title:Evaluation of the Efficacy of Kombucha-Based Drink Enriched with Inulin and Vitamins for the Management of女性中便秘促炎肠综合征：一项随机试验研究。
摘要来源：
curr dev nutr。 2023年12月; 7（12）：102037。 EPUB 2023 11月24日。PMID： 38149073 38149073 Pilipenko, Alina V Vlasova, Alla A Kochetkova
Article Affiliation:Vasily A Isakov
Abstract:BACKGROUND: Constipation-predominant irritable bowel syndrome (IBS-C) mainly affects females, and dietary interventions for symptom由于患者的依从性较低，缓解通常会产生差的结果。功能食品的发展products enriched with dietary fibers may increase patients adherence to a healthy diet and relieve IBS-Сsymptoms.
OBJECTIVE: This proof-of-concept, open-label, randomized controlled pilot study is aimed to evaluate the efficacy of kombucha enriched with inulin and vitamins in females with IBS-C.
METHODS: Forty females with IBS-C were randomly assigned to receive either 220 mL of kombucha enriched with inulin (2.53 g/220 mL) and vitamins (B1 - 0.59 mg, B2 - 0.55 mg, B3 - 5.9 mg, B6 -0.7 mg和叶酸-81.4μg/220 mL）或水10 d。在研究的第5、9和14天，使用5点李克特量表评估了粪便频率，布里斯托尔粪便量表评分（BSS）和腹部症状。使用视觉模拟量表对饮料的可口性进行评估。
结果： 10 d后，康普茶组显示了S s与对照相比，粪便频率的敏感增加（0.60±0.31-0.85±0.19次/d; 0.004）（0.63±0.33，而0.72±0.28; = 0.6）。康普茶组中BSS的平均值增加（3.0±1.2-4.4±1.0; 0.001），而它们在对照中保持不变（2.9±1.2，而3.4±1.2; 0.6; 0.6）。 The kombucha group also experienced a significant decrease in the feeling of incomplete bowel emptying (1.88±0.78 compared with 1.41±0.56 points;0.015), which was not observed in the control group.
CONCLUSIONS: Short-term consumption of kombucha enriched with inulin and维生素与粪便频率的增加，BSS的改善以及IBS-C女性中不完全肠排空的感觉减少有关。有必要证明进一步的大规模临床试验，该试验研究了富含丁丁蛋白和维生素在IBS-C患者中的康普茶的功效。
试验注册号： 该试验在clinicaltrials.gov上注册为NCT05164861（== https：//clinicalicals.gov/study/study/study/study/nct05164861？ 2021）。