Naringin通过调节大鼠模型中的一氧化氮水平来保护内脏免受缺血/再灌注损伤

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我们研究了纳雷林蛋白对肠损伤的小肠，肝脏，肾脏和肺恢复的影响。将大鼠随机分为四组八组。 A组是假控制； B组缺血2小时； C组缺血2小时，并重新灌注2小时（I/R）； D组在缺血后用50 mg/kg Naringin处理，然后再灌注2小时。通过免疫标记检测到内皮一氧化氮合酶（ENOS）和诱导型一氧化氮合酶（Inos）表达。我们还测量了精氨酸酶活性，一氧化氮（NO）和总蛋白质的量。小肠，小肠中的肝和肾脏的iNOS显着增加。仅在小肠中，iNOS显着降低。在小肠，小肠，肝脏和肺中，eNOS的eNOS显着增加。组的小肠，小肠，肝脏和肺的eNOS降低了。 however, eNOS was decreased in the kidney in group C and increased in the kidney in group D. The amount of NO was decreased significantly in all tissues in group D, but arginase activity was decreased in the small intestine and lung, increased in the kidney and remained unchanged in the liver in group D. The total protein increased in the small intestine and liver in group D, but decreased significantly in the kidney and lung in group D. Naringin had significant,通过降低无水平，平衡iNOS和eNOS表达式并减少，对I/R的生化参数的有益影响精氨酸酶活性。