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Abstract Title:Melatonin at repeated doses alleviates hyperglycemia-exacerbated cerebral通过抗炎和抗凋亡时，72H处的缺血 - 再灌注损伤。
摘要来源：
ibro NeurosciRep。2024Jun; 16：418-427。 EPUB 2024 3月5日PMID： 38500787 38500787 Affiliation:
Qian Xu
Abstract:OBJECTIVE: We aimed to investigate how hyperglycemia would exacerbate cerebral ischemia-reperfusion injury (CIRI) in a rat model of type 1 diabetes mellitus (T1DM) and explore the beneficial effects of multiple doses of T1DM诱导的CIRI中的褪黑激素。
方法： t1DM rat model was induced with streptozocin, and melatonin (10 mg/kg) was injected at 0.5 h before ischemia as well as at 24 and 48 h after reperfusion.
RESULTS: When compared to normoglycemic (NG) rats, T1DM rats had CIRI之前的高血糖症和体重减轻。尽管缺血和初始再灌注相当，但T1DM大鼠的体重减轻较大，神经系统缺陷较差，并且比NG大鼠在CIRI之后的NG大鼠的体积较差和梗塞量更大。活化B细胞（NF-κB）途径的核因子kappa-light链 - 增强途径的持续激活，而不是凋亡或calpains的持续激活是T1DM介导的CIRI在72H时加重CIRI的关键因素。尽管缺乏对基线高血糖，缺血和初始再灌注的影响，但多剂量的褪黑激素减少了CIRI的体重减轻，神经系统缺陷，T1DM大鼠在72H时的体积减轻。与使用CIRI的媒介物处理的T1DM大鼠相比。受益icial effects of melatonin treatment included decreased activation of NF-κB pathway, apoptosis and calpains, leading to reduced expression of inducible nitric oxide synthase and enhanced neuronal density.
CONCLUSION: Melatonin at multiple doses can alleviate T1DM-mediated通过抗炎和抗凋亡加剧CIRI在72H时加重。