韩国红人人参提取物和人参皂苷RG3具有抗尿素作用

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Korean Red Ginseng extract and ginsenoside Rg3 have anti-pruritic effects on氯喹通过抑制MRGPRA3/TRPA1介导的途径而引起的瘙痒。

j Ginseng res。 2018年10月； 42（4）：470-475。 EPUB 2017年5月18日。PMID： 30337807 30337807 Shim

wook-joo lee

背景： 先前发现韩国红色人参水提取物（KRGE）抑制了历史胺诱导的ITCH信号通道，使其内部介绍了外围感觉neurseral neurseral sensory neursor neurne path。因此，在本研究中，我们研究了KRGE是否抑制了氯喹（CQ）诱导的另一种独特的瘙痒途径。代表histamine-independent pathway mediated by MrgprA3 and TRPA1.

Methods: Intracellular calcium changes were measured by the calcium imaging technique in the HEK293T cells transfected with bothand("), and in primary culture of mouse dorsal root ganglia (DRGs). Mouse进行了刮擦行为测试，以验证KRGE和GINSENOSIDE RG3的建议抗尿素作用。

结果： cq-cq诱导的cainflux被krge（10μg/ml）dedose强烈抑制。 CQ-induced Cainflux in. Moreover, both KRGE (10μg/mL) and Rg3 (100 μM) suppressed CQ-induced Cainflux in primary culture of mouse DRGs, indicating that the inhibitory effect of KRGE was functional in peripheral sensory neurons.tests revealed that not only KRGE (100 mg) suppressed CQ-induced scratching in mice [bouts of scratching: 274.0±51.47（对照）vs. 104.7±17.39（krGE)], but also Rg3 (1.5 mg) oral administration significantly reduced CQ-induced scratching as well [bouts of scratching: 216.8 ± 33.73 (control) vs. 115.7 ± 20.94 (Rg3)].

Conclusion: The present study verified that KRGE and RG3对CQ诱导的瘙痒具有很强的抗乳脂效应。因此，KRGE是一种有前途的抗尿素剂，在外围感觉神经元水平上均抑制组胺依赖性和非依赖性性部。