摘要标题：
afff> prenvianoct a prenvianolic actial crialcip a and salvianolic actersist a and salvianolic contersist PDGF-C/PDGFR-α信号通路。
摘要来源：
植物医学。 2022年11月; 106：154414。 EPUB 2022 8月27日。PMID： 36057144 Qi Feng，Yingjin Qiao，Pei Wang，Jun Li
文章隶属关系：lan yao
摘要：
背景： 肾脏纤维化（rif）是各种肾脏肾脏（rif）的肾脏肾脏疾病（ESR）肾脏（ESR） （CKD），与肾功能障碍和患者预后密切相关。 salvianolic Acid A（sal a）和Salvianolic Acid B（Sal B），从中分离出来中药salviae miltiorrhizae已被证实会对肝脏，心脏和肾脏产生抗纤维化作用。 However, the precise molecular mechanism underlying the nephroprotective effects of Sal A and Sal B, and whether there is a difference between the two in RIF are still unclear.
PURPOSE: This study investigated the pharmacological effects of Sal A and Sal B in RIF and explore the underlying mechanisms by in vivo and in vitro实验。
方法： 通过评估与肾脏组织学，肾脏组织学，肾素protinal nag，urrary protinary nag，urrinaryβ2mictirul等肾功能相关的参数来评估sal a，sal b和sal a+b的肾脏保护作用。此外，还检测到与RIF相关的标记，例如CTCF和PAR3。此后，PDGF-C/PDGFR-α信号通路，凋亡和内质RE的相关蛋白质或基因水平ticulum stress (ERS) were determined by western blot, real-time PCR, flow cytometry or immunofluorescence staining.
RESULTS: In vivo, the results showed that Sal A, Sal B and Sal A+B partially improved kidney dysfunction, increased the expression of Par-3 and reduced the expression of CTGF，PDGF-C和PDGFR-α。在体外，结果还表明，SAL A，SAL B和SAL A+B通过调节PDGF-C/PDGFR-α信号通路。 PDGF-C/PDGFR-α信号通路通往RIF，并建议SAL A，SAL B和SAL A+B被认为是改善RIF的潜在治疗剂。