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Abstract Title:The Protective Potential ofL. Berry Extract against Cadmium-Induced Kidney Damage: A Study in an Animal Model of Human Environmental Exposure to This Toxic Element.
Abstract Source:Int J Mol Sci. 2023年7月19日； 24（14）。 Epub 2023 Jul 19. PMID: 37511414
Abstract Author(s):Nazar M Smereczański, Małgorzata M Brzóska, Joanna Rogalska, Tomasz Hutsch
Article Affiliation:Nazar M Smereczański
Abstract:The impact of cadmium (Cd) on the function and structure of the kidney and the potential protective effect of an extract fromL. berries were investigated in a rat model of low- and moderate-level environmental exposure to this heavy metal (1 and 5 mg Cd/kg feed for up to 24 months).敏感的生物标志物of Cd-induced damage to the kidney tubules (N-acetyl-β-D-glucosaminidase (NAG), alkaline phosphatase (ALP),β2-microglobulin (β2-MG), and kidney injury molecule-1 (KIM-1) in the urine), clinically relevant early markers of glomerular damage (albumin in the urine and creatinine clearance), and other markers of the general functional status of this organ (urea, uric acid, and total protein in the serum and/or urine) and Cd concentration in the urine, were evaluated. The morphological structure of the kidney and inflammatory markers (chemerin, macrophage inflammatory protein 1 alpha (MIP1a), and Bcl2-associated X protein (Bax)) were also estimated.低水平和中度暴露于CD会导致肾小管和肾小球的功能和结构损害。莓提取物的共同给药可显着保护这种有毒因素的有害影响。总之，即使是低水平的长期接触CD也会构成肾脏损伤的风险，而摄入aroni浆果产品可以有效地保护这种结果。