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Abstract Title:Morphological changes in the fetal kidney induced by exposure to fluoride during怀孕。
摘要来源：
环境Toxicol Pharmacol。 2024年9月; 110：104545。 Epub 2024 Aug 28. PMID: 39208996
Abstract Author(s):Esaú Montañez-Rodriguez, Sabino Hazael Avila-Rojas, Ariana Guadalupe Jimenez-Dorantes, Juan Carlos León-Contreras, Rogelio Hernandez-Pando, JoséManuel Arreola-Guerra, Casimiro Gerarduzzi, María Estela Meléndez-Camargo, Luz M Del Razo, Olivier Christophe Barbier
Article Affiliation:Esaú Montañez-Rodriguez
Abstract:To determine if fluorides established negative impact on adult kidney health begins during gestation, an intergenerational model of Wistar rats was exposed to two dos交配前20天和妊娠期间（20天）前20天（20天）的氟化物（2.5或5.0mg/kg/day）。结果表明，将氟化物分布在羊水和胎儿中，导致体重较低，胎儿限制更明显，肌酐，渗透性和羊水量减少。 At the kidney level, less development in the nephrogenic and cortical zones was observed in the fluoride treatment groups, with an imbalance in the number of glomeruli and "S" shaped bodies, an increase in the immunoexpression of the marker of proliferation Ki-67 in the nephrogenic zone, an increase in the expression of Wnt4 and more maturation of the renal tubules, indicating that fluoride exposure during怀孕改变了肾脏的发育并促进肾小管段的早期成熟。