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Abstract Title:Early kidney damage induced by subchronic exposure to PMin rats.
Abstract Source:
部分纤维毒素。 2016 12 12; 13（1）：68。 EPUB 2016 12月12日。PMID： 27955691 27955691 Uribe-Ramírez, J Narváez-Morales, A De Vizcaya-Ruiz, O Barbier
Article Affiliation:O G Aztatzi-Aguilar
Abstract:BACKGROUND: Particulate matter exposure is associated with respiratory and cardiovascular system功能障碍。最近，我们证明了也称为PM的细颗粒修改了与肺，心脏和肾脏调节有关的血管紧张素和心动激素系统的某些成分的表达。内分泌肾功能与血管紧张素和心动激肽的调节有关，即使这些系统的微小改变也可能损害。 We hypothesized that exposure to PMcan contribute to early kidney damage as a consequence of an angiotensin/bradykinin system imbalance, oxidative stress and/or inflammation.
RESULTS: After acute and subchronic exposure to PM, lung damage was confirmed by increased bronchoalveolar lavage fluid （BALF）差异细胞计数和表面活性剂蛋白A水平的降低。我们观察到PM暴露后血压，尿量和水消耗的统计学意义增加。此外，在亚基PM暴露后观察到早期肾脏损伤标志物的水平增加：在暴露的第一，第二，第六和第八周，最敏感的标记物，β-2-微球蛋白和胱抑素-C的升高。另外，SPE水平降低CICIAC细胞因子（IL-1β，IL-6，TNF-α，IL-4，IL-10，INF-γ，IL-γ，IL-17A，MIP-2和RANTES），以及上调的血管紧张素标记物和胸骨蛋白系统标记物以及耗尽的抗氧化剂反应的指标，也被观察到。 All of these effects are in concurrence with the presence of renal histological lesions and an early pro-fibrotic state.
CONCLUSION: Subchronic exposure to PMinduced an early kidney damage response that involved the angiotensin/bradykinin systems as well as antioxidant and immune imbalance.我们的研究表明，PMCAN引起的全身性失衡不仅影响心血管系统，而且还会影响肾脏，这也可能总体上有助于与PM相关的疾病。