salvianolic c抑制上皮 - 间质转变，并改善肾小管纤维纤维化纤维化

ming wu

背景： salvianolic Acid c（SAC）是一种自然化合物，它是一种自然化合物，它可以从The Thathat中避免肾脏疾病。 The aims of this work were to explore the effect of SAC on kidney tubulointerstitial fibrosis and study the associated mechanism.

METHODS: Models for unilateral ureteral obstruction (UUO) and aristolochic acid I (AAI) were established in mice to study renal微管间质纤维化。大鼠肾脏成纤维细胞（NRK-49F）and human kidney epithelial cells (HK2) were used as cellular models to evaluate the effects of SAC on kidney fibrosis.

RESULTS: Treatment with SAC for two weeks reduced the level of renal tubulointerstitial fibrosis in UUO- and AAI-induced fibrotic kidneys, as demonstrated by Massons染色和蛋白质印迹。 SAC以剂量依赖性的方式抑制NRK-49F细胞中的细胞外基质蛋白表达和TGF-β刺激的HK2细胞。此外，SAC抑制了肾纤维化动物和细胞模型以及EMT相关的转录因子蜗牛蜗牛中上皮 - 间质转变（EMT）因子的表达。此外，SAC在两个小鼠模型和肾细胞的纤维化肾脏中抑制了与纤维化相关的信号通路SMAD3。

结论： 我们通过Emt和Amelorialsials intemants intersans intemans intemants intemants intemants in consections in s and s clast。转化生长因子-β（TGF-β）/SMAD的信号传导途径的NT。