星形镜IV改善肾功能和纤维化

Xiaolei Wang

Background: Podocyte dedifferentiation and mesangial cell (MC) activation play an important role in many glomerular diseases associated with fibrosis. microRNA-21（miR-21）与肾纤维化密切相关，但未知miR-21是否以及如何促进podocyte de分化和MC激活以及黄色盐IV（AS-IV）是否通过调节miR-21来改善肾功能和纤维化。

材料和方法：

Conclusion: Our results indicated that AS-IV ameliorates renal function and renal fibrosis by inhibiting miR-21 overexpression-induced podocyte dedifferentiation and MC activation in diabetic 肾脏疾病。这些发现为未来研究AS-IV作为肾小球疾病管理的潜在治疗剂的方法铺平了道路。