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Abstract Title:Anti-leukemic and anti-angiogenic effects of d-Limonene on K562-implanted C57BL/6小鼠和小鸡绒毛膜膜模型。
摘要来源:
动物模型Exp Med。 2018年12月; 1(4):328-333。 EPUB 2018 11月21日。pmid: 30891583”> 30891583 Chaudagar, Manish Nivsarkar, Anita A Mehta
Article Affiliation:Bhavini B Shah
Abstract:Background: d-Limonene, a monoterpene from citrus fruit has been found to have chemopreventive and chemotherapeutic activities in various types of癌症。在这项研究中,我们评估了D-二烯对C562诱导的慢性髓样白血病模型(CML)在C57BL中的体内效应/6小鼠。
方法: 在免疫功能低下的C57BL/6小鼠中,K562细胞的尾静脉注射模型是开发的,并评估了该疾病特征。用D-二烯烯处理小鼠并评估血液学参数。 We also evaluated the effect of d-Limonene on angiogenesis using the chick chorioallantoic membrane (CAM) assay.
Results: In a complete blood count, a significant dose-dependent reduction in white blood cell, neutrophil and lymphocyte counts, but an elevation in red blood cell count and与疾病控制或未经治疗组相比,使用D-二烯烯处理观察到血红蛋白含量。在CAM分析中,与车辆处理组相比,D-二烯在治疗组中的血管数量显着减少。
结论:tudies表明,D-二烯在CML处理中具有有希望的抗白血病和抗血管生成作用。