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Abstract Title:Pachymic acid protects H9c2 cardiomyocytes from lipopolysaccharide-induced inflammation and apoptosis by抑制细胞外信号调节的激酶1/2和p38途径。
摘要来源：
mol Med MedRep。2015Aug; 12（2）：2807-13。 EPUB 2015年4月30日。pmid： 259366656“ Qing-Qing Wu, Rong Jiao, Zheng Yang, Meng-Qiao Zhou, Qi-Zhu Tang
Article Affiliation:Fang-Fang Li
Abstract:Pachymic acid (PA), a lanostane-type triterpenoid and the major component of Poria cocos alcoholic extracts, has various pharmacological effects, including anti-inflammatory,抗氧化和抗凋亡。但是，很少有研究研究PA对Lipopo的影响溶酶（LPS）诱导的H9C2细胞凋亡和炎症，或鉴定出这些作用的可能机制。在本研究中，通过LPS刺激H9C2心肌细胞，并用或不使用PA处理。用PA处理后，LPS诱导的LPS肿瘤坏死因子-α，白介素（IL）-1和IL-6的mRNA表达水平升高。 PA also attenuated LPS-induced apoptosis, as determined by a terminal deoxynucleotidyl transferase dUTP nick end labeling assay, and regulated the LPS-induced protein expression levels of caspase 3, 8 and 9. Furthermore, the phosphorylations of extracellular-regulated kinase (Erk)1/2 and p38 in the LPS-treated H9c2 cells were inhibited by PA.这些结果表明，使用PA的治疗可以防止LPS诱导的心肌细胞炎症和凋亡反应，这可能是通过抑制ERK1/2和p38途径介导的。
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