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Abstract Title:Onion Peel Extract Prevents Intestinal Inflammation via AMK-Activated Protein Kinase Activation in CACO-2/HT-29细胞。
摘要来源：
营养素。 2024年10月24日； 16（21）。 EPUB 2024 10月24日。PMID： 39519442 Sun-Ok Lee，Hye，Hye Won Won won Kang
文章隶属关系：olugbenga balogun
摘要：
背景： 肥胖饮食会导致肠道炎症和功能障碍。在体外研究中，多酚对减少炎症有积极影响。但是，由于胃肠道消化过程的结构改变，它们在体内系统中的生物活性可能并不相同。这个St的目的udy was to investigate the anti-inflammatory effect of onion peel and its major bioactive compound, quercetin, in the intestine and further examine the impact of intestinal digestion on this effect.
METHODS: Onion peel extract (OPE) and quercetin (Q) were digested using gastrointestinal在体外消化酶，然后将其处理成脂多糖（LPS）刺激的Caco-2/HT-29细胞。 Genes and proteins related to tight junction, inflammation, and epithelial integrity were measured.
RESULTS: OPE and digested OPE (DOPE) had a higher protective effect on LPS-induced tight junction and inflammatory genes and paracellular permeability than Q and digested Q (DQ).涂料比OPE更有效，而消化并未改变Q的活性。通过抑制核因子kappa b通过抑制核因子kappa b，OPE和Q的抗炎作用通过AMP激活的蛋白激酶激活的无声交配类型信息法规2。