摘要来源： 细胞mol Biol Lett。 2017; 22：19。 EPUB 2017年9月4日。PMID： 28878808 28878808
GloriaGutiérrez-Venegas
摘要：
感染性心内膜炎中的炎症反应是卟啉单胞菌。这是一种从慢性牙周炎患者那里收集的革兰氏阴性细菌。脂波利从牙龈疟原虫获得的糖（LPS）促进了白介素-1（IL-1），IL-6和肿瘤坏死因子alpha（TNF-α）的表达。 Flavonoids are thought to participate in processes that control inflammation, such as the expression of cyclooxygenase-2 (COX-2).
METHODS: We investigated the effects of luteolin, quercetin, genistein and quercetagetin on cardiomyoblasts treated with LPS alone or in结合以下抑制剂p38（SB203580），ERK（PD98059），JNK（SP600125）和PKC（Calphostin C）结合使用1小时。 The kinase activation and COX-2 expression levels were determined at the gene and protein levels.
RESULTS: These flavonoids are considered to inhibit the activation of mitogen-activated protein kinase (MAPK) and the degradation of inhibitor of kappa B-alpha (IκB-α).他们还在Cox-2表达中起作用。
conclusion： 我们得出的结论是，测试的类黄酮抑制了H9C2细胞中LPS诱导的炎症反应。