atti-In-inflamp water water water water water water water water wall with raw traw draw draw traw。脂多糖。
摘要来源:
营养素。 2018年5月21日; 10(5)。 EPUB 2018年5月21日。PMID: 29883374“> 29883374 Kim, Do-Hoon Kim, Tae Hee Lee, Mi Suk Kang, Wansu Park
Article Affiliation:Young-Jin Kim
Abstract:The dry root of(Oliv.) Diels, also known as"female ginseng”, is a popular herbal drug amongst women, used to treat a variety of health issues and cardiovascular diseases.这项研究的目的是评估根提取物(ASW)抗炎作用的详细分子机制。 ASW对脂多糖(LPS)的抗炎作用通过基于四唑的比色测定法(MTT),GRIESS试剂测定法,多重细胞因子测定,实时逆转录聚合酶链(RT-PCR)和Fluo-4钙测定法评估了uced Raw 264.7小鼠巨噬细胞。 ASW以最高200µg/ml的浓度恢复了RAW 264.7的细胞活力。 ASW显示出明显的抗炎作用。 ASW表现出IC = 954.3,387.3,191.7,317.8,1267.0,347.0,347.0,110.1,573.6,1171.0,732.6,732.6,980.8,125.0和257.0 g/ml interleukin(IL)-6,tumor necristive active(IL)tumor necristive active(TNACTIMIVITIST)(TNF) - (MCP)-1, regulated on activation, normal T cell expressed and secreted (RANTES), granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage colony-stimulating factor (GM-CSF), vascular endothelial growth factor (VEGF), lipopolysaccharide-induced CXC chemokine (LIX), macrophage inflammatory protein (MIP)-1α,MIP-1β,MIP-2,IL-10和细胞内钙。另外,ASW抑制了LPS-InduCED的一氧化氮和LPS诱导的CHOP(GADD153),Janus激酶2(JAK2),转录1(STAT1)的信号转换器和激活剂的MRNA表达(STAT1),第一个凋亡信号受体(FAS)和C-FOS,NOS2,NOS2和PTGS2(COX2)(<0.05)(<0.05)。数据表明,ASW通过NO-Bursting/Calcium介导的JAK-STAT途径对LPS诱导的RAW 264.7发挥抗炎作用。