单击此处阅读完整的文章。 摘要bee bee bee hearny septial supporiation sublistial suppoical suppoical subistial subistial subistial subistial subistronics conlions conlions conlions conlions conlions conlions。通过调节NRF2，NF-κB和p38 MAPK。
摘要来源：
Nutr Metab（Lond），炎症和氧化应激。 2019; 16：15。 EPUB 2019 2月27日。PMID： 30858869 Ab Hamid, Huzwah Khazaai, Abdulmannan Fadel, Ayman M Mahmoud
Article Affiliation:Yazan Ranneh
Abstract:Background: Epidemiological and experimental studies have extensively indicated that chronic subclinical systemic inflammation （CSSI）和氧化应激是多种慢性疾病的危险因素，包括癌症，关节炎，2型糖尿病，以及心血管和神经退行性疾病。 This study examined the protective effect of stingless bee honey (SBH) supplementation against lipopolysaccharide (LPS)-induced CSSI, pointing to the possible involvement of NF-κB, p38 MAPK and Nrf2 signaling.
Methods: CSSI was induced in male Sprague Dawley rats by intraperitoneal injection of LPS three times per week for 28 days, and SBH (4.6 and 9.3 g/kg/day) was supplemented for 30 days.
Results: LPS-induced rats showed significant leukocytosis, and elevated serum levels of CRP, TNF-α，IL-1β，IL-6，IL-8，MCP-1，丙二醛（MDA）和8-羟基-2-脱氧氧烷（8-OHDG）伴有抗氧化剂降低。用SBH处理可显着改善炎症标记，MDA和8-OHDG，以及LPS诱导的大鼠的抗氧化剂增强。此外，SBH降低了NF-κBP65和P38 MAPK，并增加了NRF2 ExpresLPS诱导的大鼠的肝脏，肾脏，心脏和肺中的sion。 Furthermore, SBH prevented LPS-induced histological and functional alterations in the liver, kidney, heart and lung of rats.
Conclusion: SBH has a substantial protective role against LPS-induced CSSI in rats mediated via amelioration of inflammation, oxidative stress and NF-κB，p38 MAPK和NRF2信号传导。