蓝莓提取物通过激活FXR/TGR5信号传导途径和调节肠道微生物群。
摘要来源：
j s sci food Agric，通过激活FXR/TGR5信号传导途径和调节脂肪糖诱导的小鼠炎症反应。 2023年7月; 103（9）：4638-4648。 EPUB 2023 3月31日。PMID： 36935348“> 36935348 Wen Qin，Yang Cao，Zizhong Tang，Hua Li，Xinjie Hu，Zhengfeng Fang，Shanshan Li，Zhiqing Huang，Hong Chen
文章隶属关系：shanshan zhou
shanshan zhou 摘要：p>
方法： 三十雄性公里小鼠被随机分为三组：con（控制饮食）组； LPS（LPS刺激）组； and LPS + BE (LPS stimulation, 5% BE intervention) group.
RESULTS: our results showed that, compared with the LPS group, the addition of BE decreased the level of inflammatory factors in serum and tissues, inhibited the TLR4/MyD88 signaling pathway, protected the intestinal barrier and activated FXR/TGR5，与肠道微生物群有关（尤其是Akkermansia）。 The active component (e.g., cyanidin 3-O-glucoside, C3G) in BE may be an important factor in regulating gut microbiota.
CONCLUSION: BE alleviated the inflammatory response mainly by activating bile acid receptor expression and regulating the gut microbiota;这效果可能与BE中的生物活性物质的组成有关。©2023化学工业学会。