固体烯酮对细菌脂多糖（LPS）诱导的抑郁症小鼠的抗抑郁样作用。
摘要来源：
capen capen capen res res。 2020 10 1; 395：112863。 EPUB 2020 8月17日。PMID： 32818537 Alves，Daniela Miorando，Jackeline Ernetti，Kelly Alievi，Gabriela Adriany Lisboa Zilli，PatríciaZanotelli Serpa，Cristian Alex Dalla Vecchia，Luisa Vecchia，Luisa vecchia，Luisa Mota Mota Da Silva Locateli
Abstract:BACKGROUND: Considering the pharmacological potential of solidagenone from Solidago chilensis, the present investigation was carried out to evaluate its antidepressant-like effect in mice with bacterial lipopolysaccharide (LPS)-induced depressive like behavior and its mode of action thr
材料和方法： 在预防性测试中，将小鼠用固体型（1、10或100 mg/kg，p.o）预处理小鼠，并在预防性测试中预处理小鼠，并在预防性测试中进行预处理。在治疗测试中，将小鼠接受LPS，并在5小时后用固体烯酮（1、10或100 mg/kg，P.O）处理。在两种实验方法中，分别在LPS给药6和24小时后将动物提交给了FAST和TST。 One hour after the TST the animals were euthanized, the blood was collected, the cortex was removed and biochemical analyzes were performed for measurement of the inflammatory and oxidative stress markers.
RESULTS: The LPS induced sickness- and depressive-like behaviors and increased the cortical activity of脊髓过氧化物酶（MPO）以及IL-6和TNF量。有趣的是，固体预处理以100 mg/kg为单位的雄激素避免了OFT的行为改变。在用固体烯酮治疗后的小鼠中，所有测试的剂量均导致TST中不动时间的减少所证明的抗抑郁样作用。 This effect was accompanied by a decrease in the MPO activity and in the IL-6 and TNF levels in the cortex in parallel to the increase in catalase activity.
CONCLUSIONS: The solidagenone has a promissor antidepressant-like potential, which can result of its beneficial action in the神经炎症过程及其在中枢神经系统处的抗氧化能力。