α脂酸可以改善成年男性后代大鼠的母体脂多糖暴露对前额叶白质的有害影响。
摘要来源：
j ch ch ch ch ch ch ch ch ch ch chem neuroanat。 2021年10月2日; 118：102038。 EPUB 2021 10月2日。PMID： 34610418> 34610418 Abdollah Amini, Fatemeh Fadaei Fathabady
Article Affiliation:Zahra Namvarpour
Abstract:BACKGROUND: Activation of the maternal immune system by lipopolysaccharide (LPS) increases the production of proinflammatory cytokines, free自由基和活性氧（ROS），所有这些物种在许多后代神经发育障碍的发病机理中起着重要作用。 α脂酸（ALA）是一种天然化合物，具有抗炎和抗氧化特性。这项研究是对驴进行的s the effect of prenatal exposure to LPS on the prefrontal white matter of rat offspring and evaluate the potential protective effects of ALA co-administration during pregnancy.
METHODS: Pregnant Wistar rats were randomly divided into six groups (n = 6 each group): (1) control, (2) received LPS（100μg/kg，妊娠第9.5天（GD 9.5）的腹膜内（IP），（3）从GD1到GD11到GD11，（4）LPS+ALA在GD9.5和ALA上接受了LPS LPS的Ala（20 mg/kg），从GD1.5和ALA收到了GD1至GD1至GD11的ALA和ALLES（5 and 6），（5 and 6），（5和Al lps 21）相应地分别为21 nefter。 pups from each mother) was harvested, and then their prefrontal white matter was separated and prepared for the ultrastructural, stereological, and molecular assays.
RESULTS: In utero exposure to LPS led to a significant decrease in nerve cell counts, ultrastructural alterations in myelinated axons, and厌恶大鼠后代前额叶中Sox10，olig1，yrf，wnt的基因表达的mal变化。 Co-administration of ALA resulted in amelioration of those abnormal changes in the LPS rat offspring.
CONCLUSION: The findings of our preclinical study, explore that prenatal ALA treatment efficiently protects the nervous system against LPS induced abnormal changes in the后代。