摘要来源: PharmaCogn Mag。 2015年5月; 11(增刊1):S6-S18。 PMID: 26109775 Aytaç Kocabaş, Seval Çınar, Denizİrtem Kartal Gökhan Sadi BACKGROUND: Mushrooms have been valued for their nutritive content and as traditional medicines;蘑菇的几种重要药用特性已在全球范围内识别出来。 目标: 研究是为了阐明四种可食用蘑菇的细胞生长抑制潜力。 Coprinus comatus(O.F. Mull。)pers。 (Agaricaceae),Tricholoma fracticum(Britzelm。)Kreisel(Tricholomataceae),Rhizopogon Luteolus fr。和Nordholm(Rhizopogonaceae),Lentinus Tigrinus(Bull。) (Polyporaceae) on hepatocellular carcinoma (HepG2) cells in conjunction with their antioxidant and antibacterial capacities. MATERIALS AND METHODS: Five different extracts of edible mushrooms were obtained using water, methanol, acetone, n-hexane and氯仿作为细胞毒性,抗氧化剂和抗菌特性的溶剂系统。
结果: c。 Comatus对HEPG2细胞系显示了大量的体外细胞毒性活性,尤其是所有提取物,尤其是氯仿50%抑制(IC50值为0.086 mg/ml)和丙酮(IC50值为0.420 mg/ml)。 Comatus的氯仿提取物具有MAX最多的β-胡萝卜素(25.94μg/mg),总酚含量(76.32μg/mg)和番茄红素(12.00μg/mg)和tigrinus乳杆菌的N-己烷提取物具有最大量的黄酮类动物(3.67μg/mg)。虽然Comatus的氯仿提取物显示出最高的2个,2-二苯基-1-苯基羟基(DPPH)捕获活性(1.579mg/ml),但从甲醇提取物(0.842 mg/ml)获得了金属螯合活性的最佳结果。 Moreover, all tested mushrooms demonstrated antibacterial activity and n-hexane extract of L. tigrinus and acetone extracts of T. fracticum were the most active against tested microorganism.
CONCLUSION: These results indicate that different extracts of investigated mushroom have considerable cytotoxic,抗氧化剂和抗菌特性,可以用作有希望的治疗源。