Rosa Laevigata水果的总黄酮表现出针对脂多糖诱导的肝损伤的保护作用

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我们先前报道了总黄酮类（TFS）对碳含碳car car car tetrachloride诱导的脂肪及其含量的脂肪的影响，

缺血再灌注损伤。但是，没有论文报告针对脂多糖（LPS）引起的肝损伤的作用。在tLPS诱导他的纸张肝损伤，并在术中对小鼠进行了7天的术中施用。检查了血清和肝组织中的生化参数，并通过透射电子显微镜，苏木精和曙红（H＆E）以及油红O染色观察到病理变化。结果表明，TFS显着降低了血清ALT（丙氨酸转移酶），AST（天冬氨酸转氨酶），TG（总甘油三酸酯）和TC（总胆固醇）水平以及相对肝脏的体重以及改善的肝脏病理学变化。此外，TFS显着降低了组织MDA（马发二醛）水平，并提高了SOD（超氧化物歧化酶）和GSH-PX（谷胱甘肽过氧化物酶）的水平。 A mechanistic study showed that the TFs significantly increased the expression levels of Nrf2 (nuclear erythroid factor2-related factor 2), HO-1 (heme oxygenase-1), NQO1 (NAD(P)H dehydrogenase (quinone 1), GCLC (glutamate-cysteine ligase catalytic subunit), and GCLM (glutamate-cysTeine连接酶调节亚基）并通过激活FXR（Farneoid X受体）针对氧化应激而降低KEAP1（KELCH样ECH相关蛋白1）水平。 Furthermore, the TFs markedly suppressed the nuclear translocation of NF-κB (nuclear factor-kappa B) and subsequently decreased the expression levels of IL (interleukin)-1β, IL-6, HMGB-1 (high -mobility group box 1), and COX-2 (cyclooxygenase-2) by activating FXR and FOXO3a (forkhead box O3) against inflammation. Besides, the TFs obviously reduced the expression levels of SREBP-1c (sterol regulatory element-binding proteins-1c), ACC1 (acetyl-CoA carboxylase-1), FASN (fatty acid synthase), and SCD1 (stearoyl-coenzyme A desaturase 1), and improved CPT1 (carnitine palmitoyltransferase 1) level by activating FXR to regulate脂质代谢。我们的结果表明，通过改变FXR介导的氧化应激，炎症和脂质代谢，TFS针对LPS诱导的肝损伤表现出保护作用，应发展ED作为将来治疗肝损伤治疗的有效食品和医疗产品。