伊朗J Pathol。 2021; 16（2）：174-180。 EPUB 2020 11月23日。PMID： 33936228 33936228 Hamideh Mortazavi, Maryam Monajjemzadeh, Vahhab Piranfar, Zahra Aalidaeijavadi, Azam Bakhtiarian
Article Affiliation:Mohammad Mahdi Zamani
Abstract:Background & Objective: Increased industrial activities leads长时间的人类接触工业污染物，例如镉（CD）。Arly肾脏和肝脏。 The goal of this study was to investigate the prophylactic effects of combined selenium (Se) and ascorbic acid supplement in rat cadmium toxicity.
Methods: Sixty adult male Wistar rats were divided to 10 groups: one control, one sham and two clusters of 4 intervention groups which were fed with 1 or 5 mg CD /kg水，持续28天。将抗坏血酸补充剂添加到四组（10 mg/L）的饮用水中。四组在第1、5、10、15、20和25天接受了腹膜内SE（1 mg/kg）。最后，通过肝和肾脏切片中的原子吸收分光光度计测量CD浓度。此外，在这些切片中研究了病理变化。
结果： 结果显示，结果显示了接收抗坏血酸和SE的体重增加，而与无维生素C和SE的体重损失相反。更强的坏死A与1 mg/kg CD（<0.05）的组相比，在组中观察到ND炎症。 In addition, cadmium level was higher in untreated groups without any supplements, significantly (<0.05).
Conclusion: Drinking water with ascorbic acid may have prophylactic effects across cadmium, and combination of Se and ascorbic acid are associated with higher prophylactic effects in both kidney and liver in大鼠降低CD毒性。