维生素B17对Ehrlich腹水癌诱导的肝毒性的肝脏改善作用

Ehab Tousson

Vitamin B17 (VB17), also known as amygdalin and laetrile, is a type of carbohydrate occurring naturally in many plants, such as apricot kernels which have obtained a great interest在癌症治疗中。这项研究旨在研究VB17针对Ehrlich腹水癌（EAC）的肝保护潜力，伴有小鼠诱导的肝损伤，DNA损伤，凋亡P53和PCNA改变。总共100只雌性小鼠分为5组（第一组，对照组；第二组，VB17组；第三组，EAC集团；第四组，预处理EAC，具有VB17；第五组，与VB17共同处理的EAC）。 Results showed that the presence of VB17 in pre-treated and co-treated groups lead to decreased DNA damage, microsomal protein, NADPH cytochrome c reductase, alpha-fetoprotein (AFP), AST, ALT, and ALP while showed increased cytochrome b5, cytochrome P450 amidopyrine N-demethylase, and aniline 4-hydroxylase compared with the EAC集团。在EAC的肝脏切片中观察到许多组织病理学的变化，因为中度纤维化和明显的肝组织弥漫性坏死，明显的炎症细胞和拥挤的血液正弦曲线。另一方面，预先处理的VB17+EAC的肝脏切片中肝细胞的改善程度适中，而肝细胞中等程度的改善，中等细胞浸润和中等的细胞质液空化的肝素液体化的肝脏中肝脏剖面的肝脏液体化。此外，肝p53和pCNA蛋白表达C中有耗尽与EAC组相比。可以得出结论，VB17对EAC细胞诱导的肝毒性具有潜在的肝保护作用。