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Abstract Title:Green coffee methanolic extract and silymarin protect against CCl4-induced hepatotoxicity in albino雄性大鼠。
摘要来源：
bmc补体医学。 2021年1月7日； 21（1）：19。 EPUB 2021 1月7日。PMID： 33413326 33413326 I Sakran, Ghena M Mohammed, Omar Bahattab, Maha J Balgoon, Mohamed A Elbakry, Nadia Bakry
Article Affiliation:Haddad A El Rabey
Abstract:BACKGROUND: During the last few decades, patients worldwide have been interested in using alternative治疗疾病的药物以避免化学药物的副作用增加。绿咖啡是未烤的咖啡种子，具有更高的与烤咖啡相比，绿原酸的安装。 Green coffee was successfully used to protect against obesity, Alzheimer disease, high blood pressure and bacterial infection.
METHODS: This study aimed to investigate the probable protective activity of the green coffee methanolic extract, silymarin and their combination on CCl-induced liver toxicity in male rats.三十个Sprague -Dawley雄性白化病大鼠分为5组； control negative (G1) just got the vehicle (olive oil) and the other four groups received CCldissolved in olive oil through an intraperitoneal injection and were divided into untreated control positive group (G2), the third group (G3) was treated with green coffee methanolic extract, the fourth group (G4) was treated with silymarin, and the fifth group (G5) was treated with a combination of green coffee methanolic extract and Silymarin在用CCL（G2）治疗的阳性对照组中，CCL诱导的毒性增加了脂质过氧化，IL-6，肾功能参数，肝功能酶，总胆固醇，甘油三甘油酯和低密度脂蛋白以及降低虹膜蛋白，抗氧化剂，CYP450和高度lipotein。肝组织也受伤。 However, treating the injured rats in G3, G4 and G5 significantly improved the altered parameters and hepatic tissues.
CONCLUSIONS: Green coffee methanolic extract, silymarin, and their combination succeeded in protecting the male rats against CCl4 hepatotoxicity due to their antioxidant 活动。 G5中混合的绿咖啡甲醇提取物与绿二鸟素混合的作用比G3中的绿咖啡甲醇提取物或G4中的绿咖啡甲醇提取物的作用更有效。