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摘要来源:
亚洲PAC J Trop Med。 2017年11月; 10(11):1054-1058。 EPUB 2017 10月27日。PMID: 29203101“> 29203101 Hassan Shafique, Zohaib Rana, Zahid Hussain
Article Affiliation:Fahad Hussain
Abstract:OBJECTIVE: To investigate the hepatoprotective efficacy of cranberry extract (CBE) against carbon tetrachloride (CCl4)-induced hepatic injury using体内动物模型。
METHODS: The hepatoprotective efficacy of CBE (200 and 400 mg/kg) was investigated against CCl4 (4 mL/kg)-induced hepatotoxicity, elevated liver enzymes [ALT (alanine aminotransferase), AST (aspartate aminotransferase), and alkaline phosphatase (ALP)],以及血清中的总蛋白质(TP)。分析。
结果: 结果表明,与未诱导的(未经疗法)的cbe相比,实验动物对CCL4的暴露确实引起了显着的肝毒性。增加抗氧化剂防御(GSH,所以与未经治疗的动物相比,D和CAT)以及治疗动物血清中的MDA水平降低。 The resulting data showed that the administration of CBE decreased the serum levels of ALT, AST, and ALP compared to the CCl4-induced group.
CONCLUSIONS: The resulting data evidenced that CBE exhibits promising hepatoprotective potential against the chemical induced hepatotoxicity, maintains homeostasis in liver酶,可以为自由基诱导的氧化应激提供明显的抗氧化剂防御。