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Abstract Title:The effect of taxifolin on high-dose-cisplatin-induced oxidative liver injury in rats.
Abstract来源:
adv Clin Exp Med。 2021年10月; 30(10):1025-1030。 PMID: 344435476“> 34435476 Suleyman,Nuri bakan
文章隶属关系:nezahat kurt
摘要:
背景: cisplatin是一种非特异性铂(基于基于的)化学疗法的化学药品,可导致radical in freadical in radical in radical。先前已经证明了出租车蛋白的抗氧化活性,据报道,在实验研究中,出租车蛋白抑制了羟基,自由基。
objecTives: 在目前的文献中没有发现研究菲脂素对顺铂诱导的氧化肝损伤的保护作用。 We aimed to determine the protective effect of taxifolin on cisplatin-induced hepatotoxicity in an experimental study.
MATERIAL AND METHODS: In total, 18 albino Wistar male rats were assigned into 3 groups: healthy controls (HC group), 5 mg/kg of cisplatin administered 8天(顺式组)和50 mg/kg的出租车蛋白 + 5 mg/kg顺铂施用8天(TCG组)。 Malondialdehyde (MDA), total glutathione (tGSH), total oxidant (TOS), and total antioxidant (TAS) capacity levels were measured in the extracted liver tissue.
RESULTS: Liver tissue MDA and TOS levels were significantly higher in the CIS group.相比之下,顺铂Al给予TGSH和TAS水平明显降低与其他组相比,一个(p <0.001)。在TCG组中,施用的顺铂 +出租车蛋白,MDA和TOS水平明显较低,而TGSH和TAS水平明显高于顺式组(p <0.001)。
substract_label”>结论:顺铂与肝损伤。