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Abstract Title:Vitamin C ameliorates high dose Dexmedetomidine induced liver injury.
Abstract Source:Bratisl Lek Listy. 2016; 117（1）：36-40。 PMID： 26810168“ Arpaci，F M Comu，L Ozturk，M kavutcu
文章隶属关系：m arslan
摘要：
背景：
MATERIAL AND METHODS: Thirty five wistar albino rats were randomly divided into 5 groups (Control (0.9 % NaCl intraperitoneally (ip), Dexmedetomidine 5μg.kg-1 (ip), Dexmedetomidine 5 μg.kg-1 ip加上维生素C（100 mg.kg-1），右美托咪定10μg.kg.kg-1 ip和右美托咪定10μg.kg.kg.kg-1ip加维生素C（100 mg.kg-1）。 Histopathological liver injury, superoxide dismutase (SOD) activity and tissue Malondialdehyde levels were investigated.
RESULTS: Hepatocyte degeneration was significantly higher in D10 group than those in other study groups (p<0.0001, p = 0.002, p<0.0001, p =分别为0.005）。同样，D10组的肝组织正弦膨胀和肝细胞坏死明显高于其他组的肝脏膨胀（p <0.0001，p <0.0001，p = 0.002，p = 0.002，p <0.0001和p <0.0001和p <0.0001，p = 0.046，p = 0.046，p <0.0001和p = 0.002）。 D10组的组织MDA水平显着高于对照组的D5+VIT C和D10+VIT C组的组织MDA（P = 0.028，P = 0.004，P = 0.031）。 D10组中的SOD酶活性显着低于对照，D5+VIT C和D10+VIT C组（P <0.0001，P = 0.023和P = 0.031分别）。
结论： 高剂量的右美托咪定可以在大鼠中诱导大鼠肝损伤和氧化应激，而维生素C进行预处理可能有效地保护肝脏的效应，可保护这种新的效果。 5，参考。