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Abstract Title:Curcumol attenuates liver sinusoidal endothelial cell angiogenesis via regulating肝纤维化中的Glis-Prox1-HIF-1α。
摘要来源：
细胞增殖。 2020年3月; 53（3）：E12762。 EPUB 2020 3月2日。PMID： 32119185“> 32119185 Wang, Yan Jia, Shijun Wang, Shanzhong Tan, Xikun Shen, Anping Chen, Jiangjuan Shao, Feng Zhang, Zili Zhang, Shizhong ZhengArticle Affiliation:
Xiang Yang
Abstract:OBJECTIVE: 由于功能障碍性肝正弦内皮细胞（LSEC），伴有异常血管结构的肝曲正弦血管生成，并具有与肝纤维发生有关的符号，这表明潜在的T用于治疗干预措施的Arget。 However, there are few researches connecting angiogenesis with liver fibrosis, and the deeper mechanism remains to be explored.
MATERIALS AND METHODS: Cell angiogenesis and angiogenic protein were examined in primary LSECs of rats, and multifarious cellular and molecular assays revealed the efficiency of姜黄素在纤维化小鼠中的干预。
结果： 我们发现姜黄素通过调节其上游介体低氧诱导因子-1α（HIF-1α）（HIF-1α）来抑制血管生成特性。一方面，通过刺猬信号传导调节了HIF-1α的转录激活，另一方面，HIF-1α的蛋白质稳定在另一方面受到了与Prospero相关的同源蛋白Box 1（Prox1）的控制。一种称为USP19的去泛素酶可以由Prox1募集，并参与HIF-1α的泛素依赖性降解。此外，我们的研究据说，刺猬信号参与Prox1转录的激活可能在体外。此外，发现姜黄素通过刺猬四氯化碳（CCL）诱导的肝纤维化小鼠在刺猬途径中改善肝纤维化和正弦血管生成。 The protein expression of key regulatory factors, PROX1 and HIF-1α, was consistent with the Smo, the marker protein of Hh signalling pathway.
CONCLUSIONS: In this article, we evidenced that curcumol controlling LSEC-mediated angiogenesis could be a promising therapeutic approach for liver纤维化。