PPAR-α激动剂和PPAR-γ拮抗剂的天然类胡萝卜素astaxanthin，通过在脂质载荷肝细胞中重新布线来减少肝脂质的积累。
抽象来源：摘要来源：摘要来源：
mol Nutr Food res res res。 2012年6月； 56（6）：878-88。 pmid： 22707263
摘要作者：Yaoyao Jia，Jin-Young Kim，Hee-Jin Jun，Sun-Joong Kim，Ji-Hae Lee，Minh Hien Hoang，Kwang-Yeon Hwang，Soo-Jong，Soo-Jong UM，Hyo Ihl ihl ihl ihl ihl ihl cang cang cang cang cang lee
大韩民国首尔韩国大学； Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.Abstract:SCOPE: A natural carotenoid abundant in seafood, astaxanthin (AX), has hypolipidemic activity, but its underlying mechanisms of作用和蛋白质靶标是未知的。 We investigated the molecular mechanism of action of AX in hepatic hyperlipidemia by measuring peroxisome proliferator-activated receptors (PPAR) activity.
METHODS AND RESULTS: We examined the binding of AX to PPAR subtypes and its effects on hepatic lipid metabolism. AX结合激活的PPAR-α，但抑制了报告基因测定和时间分辨荧光能量转移分析的PPAR-γ反式激活活性。 AX对PPARδ/β的反式激活没有影响。如表面等离子体共振实验评估，斧头直接与PPAR-α和PPAR-γ结合，具有中等亲和力。通过测量每个PPAR亚型的独特反应基因的表达来证实AX对PPAR的差异效应。 AX可显着降低脂质肝细胞中的细胞脂质积累。转录组分析表明，用AX（100μm）Onlipid代谢的刺激的净效应ic pathways were similar to those elicited by fenofibrate and lovastatin (10 μM each), with AX rewiring the expression of genes involved in lipid metabolic pathways.
CONCLUSION: AX is a PPAR-α agonist and PPAR-γ antagonist, reduces hepatic lipid accumulation通过在脂质加载的肝细胞中重新布线转录组。