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Abstract Title:Effect of vanillic acid and exercise training on fatty liver and insulin resistance in rats: Possible role of fibroblast growth factor 21 and自噬。
摘要来源：
Physiol Int。 2021年11月23日。epub 2021 11月23日。pmid： 34813496 A Shaker, Shereen M Samir, Soheir F El Bassiony, Hanaa A Abd El Moneim
Article Affiliation:Walaa O Obydah
Abstract:BACKGROUND AND AIMS: The prevalence of non-alcoholic fatty liver disease has been alarmingly increased with no lines of effective 治疗。香草酸是一种天然存在的多酚，具有有希望的治疗作用。众所周知，运动是有效的工具AGA肥胖及其后果。 Thus, we aim to study the effect of vanillic acid alone and along with exercise on fatty liver induced by a high-fat diet in a rat model and to investigate possible novel mechanisms involved in their action.
METHODS: In this study, 40 male rats were divided equally into five groups: control (standard chow diet), HFD (high-fat饮食），HFD+ VA（HFD+香草酸（50 mg/kg/day），HFD+ EX（HFD+游泳练习5天/周），HFD+ VA+ EX+ EX（HFD+ Vanillic Acid+ Vanillic Acid+ Vanillic Acid+ Vanillic Acid+游泳运动）八个星期。在合并的VA+EX组中，肝酶，胆固醇和甘油三酸酯的重量显着降低，与HFD相比，高血糖，高胰岛素血症的高度改善，因此在病理学方面也得到了反射。y或结合结合，显着增加了肝和循环的成纤维细胞生长因子21。此外，VA和游泳增加了自噬体标记LC3的免疫组织化学表达，并降低了p62的表达，在自噬过程中选择性降低了p62的表达。 这些结果表明，VA和防止脂肪肝的游泳运动以及FGF21和自噬的效果具有肝保护作用。