单击此处阅读完整的文章。大鼠模型中的氧化损伤和乙酰胆碱酯酶活性的调节。
摘要来源:
curr ther s her shurs clin。 2020; 92:100586。 EPUB 2020 APR20。PMID: 32419878 Owen n ebinama
文章隶属关系:jacob k akintunde
摘要:
背景: 世界上数百万的家庭取决于木材和生物量和生物质用于烹饪和热量。这种依赖性导致不良的毒性作用,例如眼和肺毒性。
目标: The present study examined the potential oculoprotective and pulmonary protective activity of naringin (NRG), a naturally occurring flavonoid, against wood smoke (WS)-induced toxicity in a rat model.
Methods: Forty-eight adult male albino rats were randomly distributed into six (n = 8)组。 All rats were fed, given water, and observed for 21 days, Group I (control) received only distilled water and no WS exposure, Group II was exposed to WS, Group III was exposed to WS and given 50 mg/kg/dα-tocopherol (vitamin E), Group IV was exposed to WS and given 80 mg/kg/day NRG, Group V was administered only 80 mg/kg/d NRG only, and VI组仅给予50 mg/kg/d的维生素E. WS暴露于20分钟/d。 NRG治疗对WS暴露的大鼠中NRG治疗对乙酰胆碱酯酶活性,一氧化氧化物自由基产生,丙二醛水平和抗氧化剂酶(即,超氧化物抑制酶和过氧化氢酶)的影响。 < <</p>
结果: subChronic(21天)暴露于WS引起的诱导的眼和肺毒性,表现出因细胞膜,萎缩,细胞炎症和细胞炎症的渗透而表现出的,这些细胞与抗毒剂浓度的差异相息。细胞损伤与乙酰胆碱酯酶活性和一氧化氮自由基浓度的增加有关。 WS触发的毒性通过NRG的共同给药。 (。2012; 73:xxx-xxx)。