radix paeoniae rubra通过还原细胞细胞细胞粘附分子1，血管细胞粘附分子1和血小板内皮细胞粘附分子-1表达的细胞粘附分子1，改善MRL小鼠类似MRL小鼠的狼疮肾炎。 2020年5月17日。EPUB 2020 5月17日。PMID： 32416674> 32416674 Xinchang Wang，Yongsheng fan
文章隶属关系：weijie wang
摘要：
目标： 血管炎是全身性lupus erythematosus的基本病理变化（sle）。 Radix Paeoniae Rubra（RPR）是一种传统的中国草药，具有减少血迹的功能，具有抗炎和免疫调节特性。这项研究探讨了RPR对来自PERSPE的MRL（MRL/LPR）小鼠类似狼疮症状的肾脏的影响ctive of intercellular cell adhesion molecule-1(ICAM-1), vascular cell adhesion molecule-1(VCAM-1) and platelet endothelial cell adhesion molecule-1(PECAM-1).
METHODS: Eighteen MRL/lpr lupus model mice were randomly divided into three组，模型对照组，泼尼松处理的组和RPR处理的组以及6个C57BL/6MICE被分类为对照组。 After the mice had been treated for 12 weeks, the expression of ICAM-1, VCAM-1and PECAM-1in the kidney was determined by immunohistochemistry and Reverse TranscriptionPolymerase Chain Reaction (RT-PCR).
RESULTS: After 12 weeks, there were significant differences in body weight in the model, prednisone and与正常组相比，RPR组（p <0.05）。病理观察：与模型组相比，炎性细胞的增殖渗透了肾小球和间质性细胞减少了一个和RPR组，并减少了肾脏病理损害。与模型组相比，泼尼松和RPR组的尿液蛋白水平没有显着性（p> 0.05）。与模型组相比，泼尼松组和RPR组的ICAM-1和VCAM-1的mRNA表达水平显着降低（p <0.05或p <0.01）。同时，在泼尼松组和RPR组中，在肾脏中表达的ICAM-1和VCAM-1的免疫组织化学表达显着降低（p <0.01或p <0.05）。 However, The mRNA expression level and the immunohistochemistry expressions of PECAM-1 expressed in the kidney were reduced in each treatment group (prednisone group and RPR group), but these differences were not significant (P＞0.05).
CONCLUSIONS: ICAM-1, VCAM-1 and PECAM-1 expression in the模型组显着增加。此外，RPR可以降低ICAM-1，VCAM-1和P的表达MRL/LPR狼疮小鼠中的ECAM -1与泼尼松一样有效，这可能导致泼尼松的剂量降低，从而降低毒性并提高基于泼尼松的SLE治疗的功效。