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Abstract Title:Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic函数。
摘要来源:
Biomed Opt Express。 2020年2月1日; 11(2):725-734。 EPUB 2020 1月10日。PMID: 32206394“> 32206394 Abdurashitov,Alexander Dubrovsky,Maria Klimova,Ilana Agranovich,Andrey Terskov,Andrey Terskov,Alexander Shirokov,Valeria Vinnik,Anna Kuzmina,Anna Kuzmina,Nikita Lezhnev,Inna Blokhina,Inna Blokhina,Anastassia Shnitenkova,Valery kikerfaike
有一个假设是,脑膜淋巴管(MLV)的排水和清除功能的增强可能是一个预防神经系统疾病的有希望的治疗靶点。在这里,我们研究了淋巴引流和清除的光生物调节(PBM,1267 nm)的机制。 Our results obtained at optical coherence tomography (OCT) give strong evidence that low PBM doses (5 and 10 J/cm) stimulate drainage function of the lymphatic vessels via vasodilation (OCT data on the mesenteric lymphatics) and stimulation of lymphatic clearance (OCT data on clearance of gold nanorods from the brain) that was supported by confocal imaging of clearance of FITC-dextran from the皮质通过MLV。我们假设PBM介导的淋巴管的松弛可能是增加淋巴内皮的渗透性的基础机制,该机制允许通过淋巴管运输的分子并解释PBM刺激淋巴引流和清除。这些发现为刺激MLV功能和非药物治疗的新策略开放了脑部疾病。