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Abstract Title:Health Benefits of Polyphenols and Carotenoids in Age-Related Eye Diseases.
Abstract Source:
氧化剂细胞寿命。 2019; 2019：9783429。 EPUB 2019 2月12日。PMID： 30891116“> 30891116 Tit, Esraa Ghanem, Shimpei Sato, Maiko Maruyama-Inoue, Shin Yamane, Kazuaki Kadonosono
Article Affiliation:Simona Bungau
Abstract:Oxidative stress and inflammation play a critical role in the initiation and progression of age-related ocular abnormalities as cataract, glaucoma, diabetic视网膜病变和黄斑变性。因此，具有经过证明的抗氧化剂和抗炎活性的植物化学物质，例如类胡萝卜素和多酚，在这些中可能有益于疾病。我们搜索了PubMed和Web of Science数据库，以研究与年龄相关的眼科疾病中不同类胡萝卜素和多酚的好处。我们的结果表明，几种多酚（例如花青素，槲皮素和白藜芦醇）和类胡萝卜素（例如叶黄素，玉米黄质和美桑糖蛋白）显示出对上述条件的显着预防和治疗益处。 The involved mechanisms in these findings include mitigating the production of reactive oxygen species, inhibiting the tumor necrosis factor-and vascular endothelial growth factor pathways, suppressing p53-dependent apoptosis, and suppressing the production of inflammatory markers, such as interleukin- (IL-) 8, IL-6, IL-1a, and endothelial leucocyte adhesion molecule-1.消费含有这些植物化学物质的产品可能会保护这些疾病；但是，缺乏足够的人类数据。这篇评论讨论了多酚和类胡萝卜素及其对预防和治疗与年龄相关的眼部疾病的可能协同作用，这些疾病被氧化应激和炎症诱导或增强。