饮食类黄酮和与年龄相关的黄斑变性的患病率和15-y发生率。
摘要来源：
am j Clin Nutr。 2018年7月6日。epub 2018年7月6日。PMID： 299824448“> 29982448” Liew, Annette Kifley, Victoria M Flood, Nichole Joachim, Joshua R Lewis, Jonathan M Hodgson, Paul Mitchell
Article Affiliation:Bamini Gopinath
Abstract:Background: The majority of research performed to date has examined the effects of commonly已知的抗氧化剂（例如维生素C，E和A和类胡萝卜素）在与年龄相关的黄斑变性（AMD）风险和进展中。迄今为止，关于具有抗氧化剂和抗炎特性的有希望的植物化学物质的研究有限ratory study, we aimed to assess the independent associations between dietary intake of total flavonoids and common flavonoid classes with the prevalence and 15-y incidence of AMD.
Design: In this population-based cohort study, 2856 adults aged≥49 y at baseline and 2037 followed up 15 y later were included in患病率和发病率分析。使用半定量食品频率问卷（FFQ）评估饮食摄入量。通过使用USDA类黄酮，异黄酮和原腺苷蛋白数据库来评估FFQ中食品类黄酮含量的估计。 AMD was assessed from retinal photographs.
Results: In cross-sectional analysis, each 1-SD increase in total overall flavonoid intake was associated with a reduced likelihood of any AMD (multivariable-adjusted OR: 0.76; 95% CI: 0.58, 0.99).总F的饮食摄入量的每1-SD增加Lavonols和总黄酮与任何AMD的患病率降低有关[多变量调整或（95％CI）：0.75（0.58，0.97）和0.77（0.60，0.99）]。在多变量调整后，在增加总黄酮和紫杉素的摄入量（从第一个到第四四分位数）和降低了入射AMD的可能性之间，观察到了略有显着的趋势（p = 0.05）。 Participants who reported ≥1 serving of oranges/d compared with those who never consumed oranges at baseline had a reduced risk of late AMD 15 y later (multivariable-adjusted OR: 0.39; 95% CI: 0.18, 0.85).
Conclusions: Our findings suggest an independent and protective类黄酮的饮食摄入与AMD的可能性之间的关联。需要进行其他前瞻性研究来验证这些发现。