胡椒碱增强甲基甲酯和棕榈酸酯组合的抗疟疾活性

Adegbenro P Adegunloye

PURPOSE: Artemisinin combination therapies, the first-line antimalarials in Nigeria, have reportedly suffered multiple failures in malaria treatment, hence the search for novel combination of other化合物。据报道，甲基甲酯和棕榈酸酯表现出抗血统活性，但其组合的抗疟疾活性尚未表现出E评估。因此，在存在杂氨酸的情况下对甲基甲酸酯和棕榈酸酯在体外和体内进行抗性活性的组合进行评估。

材料和方法：材料和方法： > 抑制了甲基酸性和甲基甲基化的甲基化含量（甲基甲基酸酯） - 甲基酸盐和甲基化的形式（体外。 Also, the antimalarial activity of methyl gallate and palmatine combination with/without a bioenhancer (piperine) was evaluated in Plasmodium berghei NK65-infected mice.

RESULTS: Methyl gallate and palmatine in the ratio 3:2 acted synergistically in体外，具有最高的抑制作用（IC = 0.73 µg/ml）对β-毛素（血元）的形成。 3：2甲基甲酸酯和棕榈酸酯的组合在没有哌啶的情况下在体内没有抗疟疾活性，但在寄生虫降低的情况下降低了寄生虫，而在果碱存在下，寄生虫降低了40％。dose of 25 mg/kg body weight on days 6 and 8 post-inoculation in mice.

CONCLUSION: The 3:2 combination of methyl gallate and palmatine in the presence of piperine exhibited antimalarial activity in vivo, possibly by synergistic inhibition of hemozoin formation which may cause accumulation在疟原虫属的食物液泡中的血液。及其死亡。