Licochalcone A保护血液 - 乳房屏障完整性，并缓解LPS诱导的乳腺炎的炎症反应

wenjin guo

乳腺炎是一种急性乳腺炎的临床临床抗炎反应。乳腺炎的发生和发育严重干扰了女性身心健康。酚类化合物中的Licochalcone A具有抗炎特性。在这里，我们检查了Licochalcone A对血液膜屏障和炎症的影响y response in LPS-induced mice mastitis., we firstly established mice models of mastitis by canal injection of LPS to mammary gland, and then detected the effect of licochalcone A on pathological indexes, inflammatory responses and blood-milk barrier in this model., Mouse mammary epithelial cells (mMECs) were treated with licochalcone A prior to the incubation of LPS, and then the分析了炎症反应，紧密连接，这是血肿屏障的基本结构。最后，我们通过检查有丝分裂原激活的蛋白kinasemapk的激活和Akt/NF-κB信号通路和抗炎的激活来阐明抗炎机制。Theresults表明，Licochalcone A显着降低了组织病理学障碍和炎症性响应和炎症性响应，并改善了血液中甲米的整合性。其中有证明，licochalcone A抑制了LPS诱导的炎症反应，并增加了MMEC中ZO-1，occludin和claudin3的蛋白质水平。动力学study found that the anti-inflammatory effect of licochalcone A in LPS-induced mice mastitis was mediated by MAPK and AKT/NF-κB signaling pathways.Our experiments collectively indicate that licochalcone A protected against LPS-induced mice mastitis via improving the blood-milk barrier integrity and inhibits the inflammatory response by MAPK and AKT/NF-κB signaling途径。