低浓度均质化蓖麻油眼滴,用于非炎性阻塞性梅博米亚腺功能障碍。
摘要来源:
ophthalmology。 2002年11月; 109(11):2030-5。 PMID: 12414410
atbract abracsive futor(s) Yukiko Yagi, Shigeto Shimmura, Kazuo TsubotaArticle Affiliation:Eiki Goto
Abstract:OBJECTIVE: We developed low-concentration homogenized castor oil eye drops for the treatment of patients with noninflamed obstructive meibomian gland dysfunction (MGD), a major cause of lipid-deficiency dry eye, and assessed the safety, stability, and efficacy of the eye drops.
DESIGN: Randomized, double-masked, placebo-controlled crossover clinical trial.
promenti裤子: 20例非炎症MGD的患者的四十只眼睛
方法: 在对含有糖的滴滴液滴研究后,含有2%castor油,2%castor油和5%多氧乙烯果油(emlifore)的糖含量(emlifore)。 The patients were assigned randomly to receive oil eye drops or placebo six times daily for 2 periods of 2 weeks each.
MAIN OUTCOME MEASURES: At the end of each treatment period, we assessed symptoms, tear interference grade, tear evaporation, fluorescein and rose bengal scores, tear break-up time (BUT), and meibomian腺孔梗阻。还进行了安全性和稳定性测试。
结果: 症状得分,泪水干扰等级,撕裂蒸发测试结果,玫瑰孟加拉分数,玫瑰式孟加拉分数,撕裂,撕裂,以及油眼落期之后的孔口障碍物。D与安慰剂期之后的结果相比,d显着改善。没有观察到归因于眼滴的并发症。当在4度c。
结论时,油眼滴是稳定的: 结果表明蓖麻油眼滴在MGD的处理中有效且安全。这种治疗的可能机制是由于脂质扩散,米布姆表达的易于性,预防撕裂蒸发以及油眼滴的润滑作用而改善了泪液稳定性。